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KMID : 0931320140140040237
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대한상부위장관.헬리코박터학회지
2014 Volume.14 No. 4 p.237 ~ p.241
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Recent Trends of Helicobacter pylori Eradication Therapy: Focusing on First LineTreatment
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Kim Ki-Bang
Kim Yong-Sik
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Abstract
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Helicobacter pylori infection causes peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid-tissue lymphoma. H. pylorieradication has played a major role in the prevention and treatment of these diseases. The guidelines for the diagnosis and treatmentof H. pylori infection in Korea recommends standard triple therapy consisting of proton pump inhibitor, clarithromycin andamoxicillin as the first line eradication therapy and quadruple therapy including bismuth in case of clarithromycin-resistant H. pyloriinfection. However, the eradication rate of conventional first line therapy of H. pylori infection has been decreasing during the lastdecade. Recently the eradication rates of standard triple therapy in Korea is reported to be lower than 80% and sometimes even lowerthan 70% (intention-to-treat). Therefore, the need for new first line eradication regimens has been rising. Sequential therapy, concomitanttherapy and tailored therapy have been introduced as new options for first line therapy. However, they have yet to be provenas standard therapy and need further studies.
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KEYWORD
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Helicobacter pylori, Eradication
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